General Information

  • ID:  hor004919
  • Uniprot ID:  P62543
  • Protein name:  Hypertrehalosaemic neuropeptide
  • Gene name:  NA
  • Organism:  Extatosoma tiaratum (Giant prickly stick insect) (Phasma tiaratum)
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Extatosoma (genus), Tropidoderinae (subfamily), Phasmatidae (family), Anareolatae (infraorder), Verophasmatodea (suborder), Phasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QLTFTPNWGT
  • Length:  10
  • Propeptide:  QLTFTPNWGT
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Threonine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Elevate the level of trehalose in the hemolymph
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004919_AF2.pdbhor004919_ESM.pdb

Physical Information

Mass: 132499 Formula: C54H77N13O16
Absent amino acids: ACDEHIKMRSVY Common amino acids: T
pI: 6.11 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -54 Boman Index: -872
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: -789 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  2340112
  • Title:  Primary structures of hypertrehalosaemic neuropeptides isolated from the corpora cardiaca of the cockroaches Leucophaea maderae, Gromphadorhina portentosa, Blattella germanica and Blatta orientalis and of the stick insect Extatosoma tiaratum assigned by tandem fast atom bombardment mass spectrometry.